Injectable cosmetic fillers can help fill in facial wrinkles, restoring a smoother appearance. Fillers such as JUVÉDERM and Restylane are approved by the FDA to be safe and effective cosmetic injectables. Both offer several different product variations developed for specific treatment areas, such as cheekbones, the marionette lines (creases extending from the corners of the mouth downward around the chin), the lips, fine lines around the mouth and more.